A sparse proteomic risk score incorporating plasma MMP12 level improves prediction of abdominal aortic aneurysm
A biologically-plausible ProRS incorporating a single matrix metalloproteinase improved prediction of AAA over clinical factors alone. These results may be used to enhance screening strategies for AAA.
Authors
- Jakob Woerner
- Shuai Yuan (ORCID: https://orcid.org/0000-0001-5055-5627)
- Michael G. Levin (ORCID: https://orcid.org/0000-0002-9937-9932)
- Scott M. Damrauer (ORCID: https://orcid.org/0000-0001-8009-1632)
- Susanna C. Larsson (ORCID: https://orcid.org/0000-0003-0118-0341)
- Dokyoon Kim
- Michael G. Clark
Institutions
- Uppsala University (SE)
- Karolinska Institutet (SE)
- Philadelphia VA Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-18
- DOI
- https://doi.org/10.64898/2025.12.16.25341932
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- VIVA Foundation for Children with Cancer
- Stiftelsen Olle Engkvist Byggmästare
- Vetenskapsrådet
- Uppsala Multidisciplinary Center for Advanced Computational Science