Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms
The effect of body mass on insulin secretion is continuous, more pronounced in men, driven by fat mass and waist, sustained by hyperglycaemia and by an upregulation of beta cell insulin secretion and is only partially explained by typical hormonal and metabolic consequences of obesity. We suggest that hepatic glucose overproduction contributes to the fasting hyperinsulinaemia observed in individuals with obesity.
Authors
- Nebojša Lalić (ORCID: https://orcid.org/0000-0002-8082-6560)
- Domenico Tricò (ORCID: https://orcid.org/0000-0002-7633-1346)
- Geltrude Mingrone (ORCID: https://orcid.org/0000-0003-2021-528X)
- Andrea Natali (ORCID: https://orcid.org/0000-0002-8465-7717)
- John J. Nolan (ORCID: https://orcid.org/0000-0003-3648-1590)
- Martina Chiriacò (ORCID: https://orcid.org/0000-0003-0174-4549)
- Amalia Gastaldelli (ORCID: https://orcid.org/0000-0003-2594-1651)
- Rafael Gabriel (ORCID: https://orcid.org/0000-0001-6084-6487)
- John R. Petrie (ORCID: https://orcid.org/0000-0002-4894-9819)
- Andrea Mari (ORCID: https://orcid.org/0000-0002-1436-5591)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- Scuola Superiore Sant'Anna (IT)
- King's College London (GB)
- Trinity College Dublin (IE)
- Instituto de Salud Carlos III (ES)
- Agostino Gemelli University Polyclinic (IT)
- University of Belgrade (RS)
- Escuela Nacional de Sanidad (ES)
- Istituto di Fisiologia Clinica (IT)
- Departamento de Salud (ES)
- National Research Council (IT)
- University of Glasgow (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1007/s00125-025-06643-9
- Citations
- 1
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- AstraZeneca
- European Commission
- European Foundation for the Study of Diabetes