Rauhut–Currier Reaction of Nitroalkenes with Vinyl Phosphonates: A Route to Electron Deficient Skipped Dienes
We have established an efficient transition metal-free protocol for the synthesis of activated, functionalized terminal nonconjugated 1,4-dienes (skipped dienes) via Horner-Wadsworth-Emmons (HWE) olefination of novel Rauhut-Currier (RC) adducts derived from nitroalkenes and vinyl phosphonates. This methodology offers a straightforward and practical approach to access skipped diene frameworks in moderate to good yields, highlighting its potential utility in the synthesis of complex molecules.
Authors
- Nishikant Satam (ORCID: https://orcid.org/0000-0002-8923-1053)
- Irishi N. N. Namboothiri (ORCID: https://orcid.org/0000-0002-8945-3932)
- Bidyut Prava Malik (ORCID: https://orcid.org/0009-0007-1956-7620)
Institutions
- William Paterson University (US)
- Indian Institute of Technology Bombay (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1021/acs.joc.5c02189
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00