Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma
GDF-15 may be a potential biomarker for "pre-cachexia" in the non-Hispanic White and the Hispanic population, but not non-Hispanic Black individuals. These findings underscore the unmet need to enroll non-Hispanic Black participants in clinical trials for CCa.
Authors
- Dung‐Tsa Chen (ORCID: https://orcid.org/0000-0001-5026-415X)
- Elena M. Cortizas (ORCID: https://orcid.org/0000-0002-9640-2826)
- John M. Koomen (ORCID: https://orcid.org/0000-0002-3818-1762)
- Katarzyna A. Rejniak (ORCID: https://orcid.org/0000-0003-2093-2422)
- Solomon Alhassan
- Daniel Jeong (ORCID: https://orcid.org/0000-0003-4510-5204)
- Mokenge P. Malafa (ORCID: https://orcid.org/0000-0003-2716-4315)
- Rafael Morales (ORCID: https://orcid.org/0000-0001-8261-8450)
- Wade G. Douglas (ORCID: https://orcid.org/0000-0002-6863-3504)
- Toni L. Basinski
- Nipun B. Merchant (ORCID: https://orcid.org/0000-0002-3399-9776)
- Samer Sansil (ORCID: https://orcid.org/0000-0001-8372-7149)
- Andrea B. McKee (ORCID: https://orcid.org/0000-0002-2743-4795)
- Lauren Marie Sparks (ORCID: https://orcid.org/0000-0002-8724-6016)
- J. Pablo Arnoletti
- Maria Genilo Delgado (ORCID: https://orcid.org/0000-0002-2094-977X)
- Jennifer B. Permuth (ORCID: https://orcid.org/0000-0002-4726-9264)
- Jason B. Fleming (ORCID: https://orcid.org/0000-0002-8796-5627)
- Tiffany L. Carson (ORCID: https://orcid.org/0000-0002-8180-4523)
- Daewon Kim (ORCID: https://orcid.org/0000-0001-5669-1451)
- Vic Velanovich (ORCID: https://orcid.org/0000-0003-0133-948X)
- Ghulam Rasool (ORCID: https://orcid.org/0000-0001-8551-0090)
- Jamie K. Teer (ORCID: https://orcid.org/0000-0003-4513-0282)
- José G. Treviño (ORCID: https://orcid.org/0000-0002-0265-8151)
- Tiago Biachi De Castria (ORCID: https://orcid.org/0000-0001-6832-2485)
- Sylvia L. Crowder (ORCID: https://orcid.org/0000-0003-1430-9810)
- Andrew R. Judge (ORCID: https://orcid.org/0000-0002-4488-291X)
- Nathan H. Parker (ORCID: https://orcid.org/0000-0002-8947-7942)
- Qianxing Mo (ORCID: https://orcid.org/0000-0002-0021-7694)
- Alexandra F. Tassielli (ORCID: https://orcid.org/0009-0009-1445-8227)
- Evan W. Davis (ORCID: https://orcid.org/0000-0002-5430-3934)
- Sarah M. Judge (ORCID: https://orcid.org/0000-0002-3974-0247)
- Anjuli Luthra (ORCID: https://orcid.org/0000-0002-9090-3144)
- Kevin L. Huguet
- Christopher J. Whelan (ORCID: https://orcid.org/0000-0001-7511-2603)
- Mark Bloomston
- Margaret A. Park
- Paul A. Stewart (ORCID: https://orcid.org/0000-0003-0882-308X)
- Kun Jiang (ORCID: https://orcid.org/0000-0003-4039-975X)
- Kenneth Meredith (ORCID: https://orcid.org/0000-0002-5861-8861)
- Manual A. Molina-Vega
- José M. Pimiento (ORCID: https://orcid.org/0000-0002-7237-4509)
- Kayode D. Olumoyin (ORCID: https://orcid.org/0000-0003-1569-4351)
- Lina Moreno-Urazan
- Dan Viet Tran
- Anjana A. Menon
- Pamela J. Hodul (ORCID: https://orcid.org/0000-0003-2004-2702)
Institutions
- University of Miami (US)
- Orlando Health (US)
- Virginia Commonwealth University (US)
- University of Utah (US)
- University of South Florida (US)
- Huntsman Cancer Institute (US)
- Tampa General Hospital (US)
- Moffitt Cancer Center (US)
- University of Florida (US)
- Florida Hospital Cancer Institute (US)
- Virginia Cancer Institute (US)
- Regional Health (US)
- Sarasota Memorial Hospital (US)
- St. Anthony’s Hospital (US)
- Translational Research Institute for Metabolism and Diabetes (US)
- Lakeland Regional Medical Center (US)
- Tallahassee Memorial HealthCare (US)
- Sylvester Comprehensive Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1038/s43856-025-01277-9
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- University of Miami
- Florida Department of Health
- Moffitt Cancer Center
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- National Institutes of Health
- National Cancer Institute
- Office of Behavioral and Social Sciences Research