Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma

GDF-15 may be a potential biomarker for "pre-cachexia" in the non-Hispanic White and the Hispanic population, but not non-Hispanic Black individuals. These findings underscore the unmet need to enroll non-Hispanic Black participants in clinical trials for CCa.

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Publication Details

Journal
Communications Medicine
Published
2025-12-18
DOI
https://doi.org/10.1038/s43856-025-01277-9
Primary Topic
GDF15 and Related Biomarkers
Type
article
Field-Weighted Citation Impact
0.00

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article

Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma

Dung‐Tsa Chen, Elena M. Cortizas, John M. Koomen, Katarzyna A. Rejniak et al.
Communications Medicine
GDF15 and Related Biomarkers
article

Race-based differences in serum biomarkers for cancer-associated cachexia in a diverse cohort of patients with pancreatic ductal adenocarcinoma

Dung‐Tsa Chen, Elena M. Cortizas, John M. Koomen, Katarzyna A. Rejniak, Solomon Alhassan, Daniel Jeong, Mokenge P. Malafa, Rafael Morales, Wade G. Douglas, Toni L. Basinski, Nipun B. Merchant, Samer Sansil, Andrea B. McKee, Lauren Marie Sparks, J. Pablo Arnoletti, Maria Genilo Delgado, Jennifer B. Permuth, Jason B. Fleming, Tiffany L. Carson, Daewon Kim, Vic Velanovich, Ghulam Rasool, Jamie K. Teer, José G. Treviño, Tiago Biachi De Castria, Sylvia L. Crowder, Andrew R. Judge, Nathan H. Parker, Qianxing Mo, Alexandra F. Tassielli, Evan W. Davis, Sarah M. Judge, Anjuli Luthra, Kevin L. Huguet, Christopher J. Whelan, Mark Bloomston, Margaret A. Park, Paul A. Stewart, Kun Jiang, Kenneth Meredith, Manual A. Molina-Vega, José M. Pimiento, Kayode D. Olumoyin, Lina Moreno-Urazan, Dan Viet Tran, Anjana A. Menon, Pamela J. Hodul
article en

Abstract

GDF-15 may be a potential biomarker for "pre-cachexia" in the non-Hispanic White and the Hispanic population, but not non-Hispanic Black individuals. These findings underscore the unmet need to enroll non-Hispanic Black participants in clinical trials for CCa.

Communications MedicineVol. 6(1)
University of Miami (US), Orlando Health (US), Virginia Commonwealth University (US), University of Utah (US), University of South Florida (US), Huntsman Cancer Institute (US), Tampa General Hospital (US), Moffitt Cancer Center (US), University of Florida (US), Florida Hospital Cancer Institute (US), Virginia Cancer Institute (US), Regional Health (US), Sarasota Memorial Hospital (US), St. Anthony’s Hospital (US), Translational Research Institute for Metabolism and Diabetes (US), Lakeland Regional Medical Center (US), Tallahassee Memorial HealthCare (US), Sylvester Comprehensive Cancer Center (US), The University of Texas Southwestern Medical Center (US)
U.S. Department of Defense, University of Miami, Florida Department of Health, Moffitt Cancer Center, Sylvester Comprehensive Cancer Center, University of Miami Health Systems, National Institutes of Health, National Cancer Institute, Office of Behavioral and Social Sciences Research
Openalex Percentile: Top 42%
GDF15 and Related Biomarkers
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