Characterization of the Immunogenomic Landscape of Ovarian Cancer Uncovers a Distinct Subset of Endometroid Tumors Associated with High <i>CST2</i> Expression and a Favorable Prognosis
Our study employs a multimodal latent variable model across 197 patients to identify principal drivers of immunogenomic intertumor heterogeneity. We uncover a distinct subgroup of endometrioid ovarian cancer with a unique immunogenomic signature and better prognosis and a set of collagen-related genes associated with the tumor microenvironment. This work challenges the adequacy of existing histologic classifications in capturing the molecular diversity of ovarian cancer, potentially informing more personalized treatment strategies.
Authors
- Maurizio Scaltriti (ORCID: https://orcid.org/0000-0002-5522-1447)
- Barrett Nuttall (ORCID: https://orcid.org/0000-0002-0362-229X)
- Emma V. Jones (ORCID: https://orcid.org/0000-0002-2114-8501)
- Shaan Gill (ORCID: https://orcid.org/0009-0008-2540-194X)
- Ben S. Sidders (ORCID: https://orcid.org/0000-0003-2733-3078)
- Amelia Raymond (ORCID: https://orcid.org/0009-0005-7589-6125)
- Miljenka Vuko (ORCID: https://orcid.org/0000-0001-8226-6352)
- Andrea Ennio Storti (ORCID: https://orcid.org/0009-0001-4491-7078)
- Paola Marco‐Casanova (ORCID: https://orcid.org/0009-0003-4269-8988)
- Jan Zaucha (ORCID: https://orcid.org/0000-0003-3289-4590)
- Jaclyn A. Boyle (ORCID: https://orcid.org/0009-0004-6541-8712)
- Marco Testori (ORCID: https://orcid.org/0009-0008-5515-496X)
- Felicia Ng (ORCID: https://orcid.org/0000-0001-6335-711X)
- Andreas Spitzmüller (ORCID: https://orcid.org/0000-0003-1217-7818)
- Michael Surace (ORCID: https://orcid.org/0009-0000-8326-5159)
- Felix J. Segerer (ORCID: https://orcid.org/0009-0001-2980-3080)
- Sakshi Gulati (ORCID: https://orcid.org/0009-0009-3306-3001)
- Helen K. Angell (ORCID: https://orcid.org/0000-0001-9822-4755)
- Jorge S. Reis‐Filho (ORCID: https://orcid.org/0000-0003-2969-3173)
- A Semertzidou (ORCID: https://orcid.org/0000-0001-7638-8855)
- Monica Azqueta-Gavaldon (ORCID: https://orcid.org/0009-0003-7639-6339)
Institutions
- AstraZeneca (United Kingdom) (GB)
- AstraZeneca (South Korea) (KR)
- AstraZeneca (Netherlands) (NL)
- AstraZeneca (Singapore) (SG)
- AstraZeneca (Brazil) (BR)
- AstraZeneca (Switzerland) (CH)
- AstraZeneca (Japan) (JP)
- AstraZeneca (Poland) (PL)
- AstraZeneca (Germany) (DE)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0150
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca