Inhalation of N-Chlorotaurine Is an Effective Treatment of Aspergillus fumigatus Pneumonia in Mice
Early treatment with inhaled NCT as well as prophylactic treatment demonstrated a highly significant beneficial efficacy in Aspergillus pneumonia. A concentration around 1% NCT appears to be optimal taking into account both tolerability and efficacy, which is in agreement with previous studies and case experiences in humans. Inhalation with NCT as an antiseptic and anti-infective product of granulocytes is highly promising in infections of the lower airways and should be further developed to achieve drug approval.
Authors
- Christoph A. Schatz (ORCID: https://orcid.org/0000-0001-8028-2631)
- Markus Nagl (ORCID: https://orcid.org/0000-0002-1225-9349)
- Georg Schäfer (ORCID: https://orcid.org/0009-0004-7622-7401)
- Cornelia Speth (ORCID: https://orcid.org/0000-0001-5637-5993)
- Andrea Windisch
- Günter Rambach (ORCID: https://orcid.org/0000-0002-7574-7868)
- Nadine Falbesoner
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
Publication Details
- Journal
- Journal of Innate Immunity
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1159/000550140
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund
- Bundesministerium für Bildung, Wissenschaft und Forschung