The paradoxical protective effect of chronic stress on advanced Alzheimer’s disease pathology
Chronic stress and depression attenuate CNS myeloid cells. While this has been shown to promote amyloid pathology at early stages, similar attenuation of CNS myeloid cells at the stage of established AD pathology may interfere with their transition into fully neurotoxic microglia, which cause neurodegeneration. These findings highlight the importance of tailoring microglial-targeted therapies to the stage-dependent roles of these cells during AD progression.
Authors
- Marva Lachish
- Hadar Benyamini
- Yuval Nevo (ORCID: https://orcid.org/0000-0001-6757-5675)
- Gilly Wolf
- Tamir Ben‐Hur (ORCID: https://orcid.org/0000-0003-3463-2922)
- Tal Ganz (ORCID: https://orcid.org/0000-0003-3567-9853)
- Raed Said (ORCID: https://orcid.org/0000-0003-4947-4170)
- Nina Fainstein
- Amit Lotan (ORCID: https://orcid.org/0000-0001-7628-0975)
- Tzuri Lifschytz
- Yoel Shor
- Yarden Brock
- Jonathan Gurevitz
- Lihi Sofer Stepanov
- Yara Shwaiky
Institutions
- Hebrew University of Jerusalem (IL)
- Hadassah Medical Center (IL)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1016/j.bbi.2025.106224
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00