Early Safety Results from the Phase 3b SIERRA Study of Durvalumab and Tremelimumab as First-Line Treatment for Participants with Unresectable Hepatocellular Carcinoma and a Poor Prognosis

The safety profile of STRIDE was manageable and consistent with the HIMALAYA study in participants with poorer prognosis than in HIMALAYA.

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Publication Details

Journal
Liver Cancer
Published
2025-12-18
DOI
https://doi.org/10.1159/000549955
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
Field-Weighted Citation Impact
0.00

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article

Early Safety Results from the Phase 3b SIERRA Study of Durvalumab and Tremelimumab as First-Line Treatment for Participants with Unresectable Hepatocellular Carcinoma and a Poor Prognosis

Jung Yong Hong, Adam M. Burgoyne, Robin Kate Kelley, Masatoshi Kudo et al.
Liver Cancer
Hepatocellular Carcinoma Treatment and Prognosis
article

Early Safety Results from the Phase 3b SIERRA Study of Durvalumab and Tremelimumab as First-Line Treatment for Participants with Unresectable Hepatocellular Carcinoma and a Poor Prognosis

Jung Yong Hong, Adam M. Burgoyne, Robin Kate Kelley, Masatoshi Kudo, Stephen L. Chan, Donatella Marino, Lorenza Rimassa, Joycelyn Jie Xin Lee, René Gerolami, Bruno Sangro, Qiao Li, Jee Hyun Kim, Hitomi Nakamura, Peng Sun, Dirk‐Thomas Waldschmidt, Binh V. Pham, Boris Baur
article en

Abstract

The safety profile of STRIDE was manageable and consistent with the HIMALAYA study in participants with poorer prognosis than in HIMALAYA.

Liver Cancer
AstraZeneca (United Kingdom) (GB), Humanitas University (IT), Chinese University of Hong Kong (HK), University of California, San Francisco (US), Aix-Marseille Université (FR), UC San Diego Health System (US), Samsung Medical Center (KR), Seoul National University Bundang Hospital (KR), University of California San Diego (US), Assistance Publique Hôpitaux de Marseille (FR), Prince of Wales Hospital (CN), Centro de Investigación Biomédica en Red (ES), A. O. Ordine Mauriziano di Torino (IT), Clinica Universidad de Navarra (ES), National Cancer Centre Singapore (SG), Vietnam National Children's Hospital (VN), AstraZeneca (Canada) (CA), AstraZeneca (United States) (US), University Hospital Cologne (DE), IRCCS Humanitas Research Hospital (IT), UCSF Helen Diller Family Comprehensive Cancer Center (US), Sungkyunkwan University (KR), Kindai University (JP)
AstraZeneca
Openalex Percentile: Top 45%
Hepatocellular Carcinoma Treatment and Prognosis
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