Early Safety Results from the Phase 3b SIERRA Study of Durvalumab and Tremelimumab as First-Line Treatment for Participants with Unresectable Hepatocellular Carcinoma and a Poor Prognosis
The safety profile of STRIDE was manageable and consistent with the HIMALAYA study in participants with poorer prognosis than in HIMALAYA.
Authors
- Jung Yong Hong (ORCID: https://orcid.org/0000-0003-1363-9332)
- Adam M. Burgoyne (ORCID: https://orcid.org/0000-0002-4351-9940)
- Robin Kate Kelley (ORCID: https://orcid.org/0000-0002-1984-2430)
- Masatoshi Kudo (ORCID: https://orcid.org/0000-0002-4102-3474)
- Stephen L. Chan (ORCID: https://orcid.org/0000-0001-8998-5480)
- Donatella Marino (ORCID: https://orcid.org/0000-0001-6565-0870)
- Lorenza Rimassa (ORCID: https://orcid.org/0000-0001-9957-3615)
- Joycelyn Jie Xin Lee (ORCID: https://orcid.org/0000-0002-1070-6125)
- René Gerolami
- Bruno Sangro (ORCID: https://orcid.org/0000-0002-4177-6417)
- Qiao Li (ORCID: https://orcid.org/0000-0001-7137-004X)
- Jee Hyun Kim (ORCID: https://orcid.org/0000-0003-1336-3620)
- Hitomi Nakamura
- Peng Sun
- Dirk‐Thomas Waldschmidt
- Binh V. Pham
- Boris Baur
Institutions
- AstraZeneca (United Kingdom) (GB)
- Humanitas University (IT)
- Chinese University of Hong Kong (HK)
- University of California, San Francisco (US)
- Aix-Marseille Université (FR)
- UC San Diego Health System (US)
- Samsung Medical Center (KR)
- Seoul National University Bundang Hospital (KR)
- University of California San Diego (US)
- Assistance Publique Hôpitaux de Marseille (FR)
- Prince of Wales Hospital (CN)
- Centro de Investigación Biomédica en Red (ES)
- A. O. Ordine Mauriziano di Torino (IT)
- Clinica Universidad de Navarra (ES)
- National Cancer Centre Singapore (SG)
- Vietnam National Children's Hospital (VN)
- AstraZeneca (Canada) (CA)
- AstraZeneca (United States) (US)
- University Hospital Cologne (DE)
- IRCCS Humanitas Research Hospital (IT)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Sungkyunkwan University (KR)
- Kindai University (JP)
Publication Details
- Journal
- Liver Cancer
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1159/000549955
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca