Mechanistic Study of Hypoxia-Mediated Regulation of Osteoblast Senescence via ATP6V1A-Dependent Modulation of Metabolic Remodeling
This study identifies a "Hypoxia-ATP6V1A-Oxidative Stress-Metabolic Remodeling-Anti-Senescence" axis, demonstrating that hypoxia delays osteoblast senescence by downregulating ATP6V1A, suppressing oxidative stress, and reprogramming metabolism, providing new insights and potential therapeutic targets for bone degenerative diseases.
Authors
- Bin Geng (ORCID: https://orcid.org/0000-0002-1505-3645)
- Rongjin Chen
- Hefang Xiao
- Xuening Liu (ORCID: https://orcid.org/0009-0007-3969-3093)
- Yayi Xia (ORCID: https://orcid.org/0000-0002-6758-4130)
- Changshun Chen
- Fei Yang (ORCID: https://orcid.org/0000-0001-8718-310X)
- Chenhui Yang
- Yi Chen (ORCID: https://orcid.org/0000-0001-5430-7612)
Institutions
- Lanzhou University of Technology (CN)
- Lanzhou University Second Hospital (CN)
- Orthopaedic Research (GB)
- Lanzhou University (CN)
Publication Details
- Journal
- Biology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3390/biology14121801
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00