Radiographic Fibrosis Extent Identifies Immunomodulatory Treatment Response in Hypersensitivity Pneumonitis
Visual fibrosis extent is associated with differential pulmonary function response to immunomodulatory therapy in chronic HP. Patients with limited fibrosis demonstrated improved pulmonary function compared with those with greater radiographic fibrosis. These findings may support the use of fibrosis extent as a clinical tool for treatment stratification and highlight the need for prospective trials to validate radiographic markers in guiding HP management.
Authors
- Michael R. Hamblin (ORCID: https://orcid.org/0000-0001-6431-4605)
- Bohyung Min (ORCID: https://orcid.org/0000-0001-7875-4361)
- Scott M. Matson (ORCID: https://orcid.org/0000-0002-3748-9597)
- Kerri A. Johannson (ORCID: https://orcid.org/0000-0003-1205-5511)
- Melissa Carroll
- Gregory Lee (ORCID: https://orcid.org/0000-0002-5342-964X)
- A. Mrad
- Caroline N. Muegge
- Sahil Pandya
- Emily Ianazzo
Institutions
- University of Wisconsin–Madison (US)
- University of Calgary (CA)
- University of Kansas Medical Center (US)
- University of Wisconsin Health (US)
Publication Details
- Journal
- CHEST Journal
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.chest.2025.12.007
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00