The Low Platelet Count at the Start of Atezolizumab Plus Bevacizumab Therapy for Unresectable Hepatocellular Carcinoma Predicts Deteriorated Liver Function at the Time of Disease Progression Thereafter: A Multicenter Analysis
The data suggest that the platelet count can be used to predict liver function at the time of evaluation of PD after ATZ/BEV therapy in patients with u-HCC. Treatment strategies in u-HCC patients with low platelet counts should be conducted by taking into account deterioration of liver function after ATZ/BEV therapy.
Authors
- Atsushi Ozasa
- Yoshihide Kimura (ORCID: https://orcid.org/0000-0003-4801-8384)
- Shunsuke Nojiri
- Kentaro Narita (ORCID: https://orcid.org/0000-0002-6504-9046)
- Katsumi Hayashi (ORCID: https://orcid.org/0000-0003-1092-2546)
- Kei Fujiwara (ORCID: https://orcid.org/0000-0003-4531-4444)
- Ryo Sato (ORCID: https://orcid.org/0000-0002-1340-4739)
- Atsunori Kusakabe
- Hiromu Kondo (ORCID: https://orcid.org/0000-0002-1277-6821)
- Hiromi Kataoka (ORCID: https://orcid.org/0000-0001-9491-0723)
- Kohei Okayama
- Daisuke Kato (ORCID: https://orcid.org/0000-0003-1710-4319)
- Hayato Kawamura (ORCID: https://orcid.org/0000-0002-7679-4279)
- Tsutomu Mizoshita (ORCID: https://orcid.org/0000-0003-0460-5288)
- Kentaro Matsuura (ORCID: https://orcid.org/0009-0005-0163-3971)
- Takanori Suzuki (ORCID: https://orcid.org/0000-0002-8940-2393)
- Fumihiro Okumura
- Kazuki Hayashi
- Izumi Hasegawa
- Satoshi Sobue
- Hisayo Kojima
Institutions
- Nagoya City University (JP)
- Gifu Prefectural Tajimi Hospital (JP)
- Toyokawa City Hospital (JP)
- Kasugai Municipal Hospital (JP)
- Nagasaki Rousai Hospital (JP)
- Chukyo Hospital (JP)
- Nagoya Medical Center (JP)
- Japanese Red Cross Nagoya Daini Hospital (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1111/hepr.70101
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32