Diagnostic Accuracy of Severe Acute Respiratory Infection Definitions in Hospitalized Children
In this systematic review and meta-analysis of 13 studies, the WHO 2014 SARI definition demonstrated reduced sensitivity and increased specificity in younger pediatric cohorts, suggesting that surveillance systems that rely on SARI case definitions may potentially underestimate disease burden in children.
Authors
- Shaun K. Morris (ORCID: https://orcid.org/0000-0001-9809-0822)
- Daniel S. Farrar (ORCID: https://orcid.org/0000-0002-7823-1912)
- Leo Hersi
- Haifa Mtaweh (ORCID: https://orcid.org/0000-0002-7562-549X)
- Jessie Cunningham (ORCID: https://orcid.org/0000-0002-3453-0515)
- Sanjay Mahant (ORCID: https://orcid.org/0000-0003-0487-5835)
- Peter Gill
- Nicholas Bryan (ORCID: https://orcid.org/0009-0007-2216-0362)
- Caitlyn L. Kaziev
- Tuana Kant
Institutions
- University of Toronto (CA)
- Queen's University (CA)
- Hospital for Sick Children (CA)
- Public Health Ontario (CA)
- SickKids Foundation (CA)
- Institute for Clinical Evaluative Sciences (CA)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.50298
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- Sanofi
- Public Health Agency of Canada
- Physicians' Services Incorporated Foundation
- Public Health Agency
- Hospital for Sick Children
- Canadian Institutes of Health Research