Quadrivalent Human Papillomavirus Vaccine and High-Grade Vulvovaginal Lesions
In this cohort study, vaccinated women had a lower incidence of high-grade vulvovaginal lesions compared with unvaccinated women, with a greater incidence reduction for those vaccinated at younger ages (before 17 years of age). Population-level incidence reduction was observed in cohorts vaccinated through subsidized or catch-up programs. These findings support that scaling up coverage of HPV vaccination at younger ages may help prevent high-grade vulvovaginal lesions.
Authors
- Jiayao Lei (ORCID: https://orcid.org/0000-0002-4718-1414)
- Yunyang Deng (ORCID: https://orcid.org/0000-0003-4848-2953)
- Lina Schollin Ask (ORCID: https://orcid.org/0000-0002-1328-8619)
- Tiia Lepp (ORCID: https://orcid.org/0000-0003-0331-0728)
- Shiqiang Wu (ORCID: https://orcid.org/0000-0001-6848-7714)
- Mark O. Clements (ORCID: https://orcid.org/0009-0004-9390-5171)
- Christina Carlander (ORCID: https://orcid.org/0000-0001-9962-5964)
- Hanna Milerad
Institutions
- Public Health Agency of Sweden (SE)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Region Västra Götaland (SE)
- Regional Cancer Center (US)
- Sachs' Children and Youth Hospital (SE)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1001/jamaoncol.2025.5511
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Cancerfonden
- Karolinska Institutet
- Vetenskapsrådet
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd