Knockdown of FXYD2 inhibits mepivacaine-induced cardiomyocyte injury by activating the PI3K/AKT signaling pathway
Knockdown of FXYD2 plays a key role in reducing mepivacaine-induced cardiomyocyte injury by modulating oxidative stress, apoptosis, mitochondrial function, and ER stress, mediated through the PI3K/AKT signaling cascade.
Authors
- Jiaying Chen (ORCID: https://orcid.org/0009-0008-9310-9916)
- Liping Cheng (ORCID: https://orcid.org/0000-0002-1797-8705)
- Bo Wang (ORCID: https://orcid.org/0000-0001-8104-1821)
- Xue Qiao (ORCID: https://orcid.org/0009-0000-7807-3494)
- Yuming Sun (ORCID: https://orcid.org/0009-0005-3823-5547)
Institutions
- Second Military Medical University (CN)
- Fudan University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s40001-025-03509-z
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00