Hemozoin induces neuronal injury primarily characterized by axon rupture and mitochondrial damage in experimental cerebral malaria
This study provided the first evidence to our knowledge that Hz directly adhered to neurons and underwent internalization into its cytoplasm, thereby leading to neuronal injury. These findings elucidate a potential mechanism underlying neuronal injury in ECM and inform the development of adjuvant therapies targeting Hz.
Authors
- Chao Yang (ORCID: https://orcid.org/0000-0002-1961-6898)
- Yan Shen (ORCID: https://orcid.org/0000-0001-7058-8602)
- Jiao Liang (ORCID: https://orcid.org/0000-0002-4013-7322)
- Qinghao Zhu
- Ganze Li
- Aining Zhang (ORCID: https://orcid.org/0000-0002-7859-5273)
- Duoc M. Dang
- Pengtao Li
- Tong Li (ORCID: https://orcid.org/0000-0002-2544-1254)
- Jun Wang (ORCID: https://orcid.org/0000-0003-0880-4663)
- Yuxiao Huang (ORCID: https://orcid.org/0009-0002-2055-736X)
- Yi Wang (ORCID: https://orcid.org/0000-0003-1713-071X)
- Ya Zhao (ORCID: https://orcid.org/0000-0001-8696-3454)
- Jiayi Sun (ORCID: https://orcid.org/0009-0006-2847-877X)
Institutions
- Northwest University (CN)
- Yan'an University (CN)
- Air Force Engineering University (CN)
- Xi'an Medical University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s13071-025-07102-5
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00