Efficacy of isoniazid in paediatric tuberculosis: an individual participant data meta-analysis
Our findings showed that the only predictor of unfavourable clinical outcomes was a lower BAZ. We support the current WHO-recommended dosing regimen for isoniazid. To equalise and attain our pharmacological target for all children, dosing regimens could be adjusted on NAT2 genotype and nutritional status.
Authors
- Radojka M. Savić (ORCID: https://orcid.org/0000-0003-3143-5579)
- Kelly E. Dooley (ORCID: https://orcid.org/0000-0001-9013-5256)
- Ira Shah (ORCID: https://orcid.org/0000-0002-0027-0284)
- Adrie Bekker (ORCID: https://orcid.org/0000-0003-3836-3432)
- Anna Turkova (ORCID: https://orcid.org/0000-0002-7008-4145)
- Thirumurthy Velpandian (ORCID: https://orcid.org/0000-0003-0334-5197)
- Chishala Chabala (ORCID: https://orcid.org/0000-0002-5551-5752)
- Helen McIlleron (ORCID: https://orcid.org/0000-0002-0982-6226)
- Jeremy Day (ORCID: https://orcid.org/0000-0002-7843-6280)
- Scott K. Heysell (ORCID: https://orcid.org/0000-0002-2040-0293)
- Belén Pérez Solans (ORCID: https://orcid.org/0000-0003-4621-5480)
- Heda Melinda Nataprawira (ORCID: https://orcid.org/0000-0001-8079-6544)
- Fajri Gafar (ORCID: https://orcid.org/0000-0002-0084-9018)
- Awewura Kwara (ORCID: https://orcid.org/0000-0002-1118-8331)
- Rakesh Lodha (ORCID: https://orcid.org/0000-0003-2608-1163)
- Edmund V. Capparelli (ORCID: https://orcid.org/0000-0002-1630-0505)
- Ryo Miyakawa (ORCID: https://orcid.org/0000-0002-1729-0011)
- Charles A. Peloquin (ORCID: https://orcid.org/0000-0001-9002-7052)
- Paolo Denti (ORCID: https://orcid.org/0000-0001-7494-079X)
- Agathe Béranger (ORCID: https://orcid.org/0000-0002-9751-8249)
- Louise Choo (ORCID: https://orcid.org/0000-0003-4040-1522)
- Blessed Winston Aruldhas (ORCID: https://orcid.org/0000-0002-2082-6454)
- Rovina Ruslami (ORCID: https://orcid.org/0000-0003-4995-5054)
- Jennifer J. Kiser
- Binu Mathew (ORCID: https://orcid.org/0000-0001-6532-1559)
- Tania A. Thomas (ORCID: https://orcid.org/0000-0002-3929-6369)
- Joel Tärning (ORCID: https://orcid.org/0000-0003-4566-4030)
- Aparna Mukherjee (ORCID: https://orcid.org/0000-0001-7298-5097)
- Nguyen Duc Bang
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Inserm (FR)
- University of Cape Town (ZA)
- University of Groningen (NL)
- Christian Medical College, Vellore (IN)
- University of California, San Francisco (US)
- American Association of Colleges of Pharmacy (US)
- Université Paris Cité (FR)
- Mahidol University (TH)
- Stellenbosch University (ZA)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- University of Virginia Health System (US)
- Royal Devon and Exeter Hospital (GB)
- McGill University Health Centre (CA)
- University Teaching Hospital (ZM)
- University of Florida (US)
- University of Zambia (ZM)
- University of California San Diego (US)
- University of Oxford (GB)
- Dr. Hasan Sadikin General Hospital (ID)
- Rady Children's Hospital-San Diego (US)
- MRC Clinical Trials Unit at UCL (GB)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Bai Jerbai Wadia Hospital for Children (IN)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Hôpital des Enfants (FR)
- Pham Ngoc Thach Hospital (VN)
- University College London (GB)
- McGill University (CA)
- University of Virginia (US)
- Orano (United States) (US)
- All India Institute of Medical Sciences (IN)
- University of Montana (US)
- Vanderbilt University Medical Center (US)
- Medical Research Council (GB)
- Padjadjaran University (ID)
- Florida College (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1183/13993003.01046-2025
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79