Exploring fibroblast activation protein as an early biomarker in chronic lung allograft dysfunction
FAP expression is elevated in CLAD and is associated with subsequent CLAD and survival. Tissue FAP may enable early risk stratification and inform clinical surveillance; however, given its moderate discrimination, prospective validation in multicenter cohorts is warranted.
Authors
- Haiying Sun (ORCID: https://orcid.org/0000-0002-7163-1702)
- Chitaru Kurihara (ORCID: https://orcid.org/0000-0003-3536-4675)
- Takashi Hiroshima (ORCID: https://orcid.org/0009-0002-0807-009X)
- Hiam Abdala‐Valencia (ORCID: https://orcid.org/0000-0003-3384-5299)
- Ankit Bharat (ORCID: https://orcid.org/0000-0002-1248-0457)
- Taisuke Kaiho (ORCID: https://orcid.org/0009-0003-1056-5929)
- Yuanqing Yan (ORCID: https://orcid.org/0000-0002-0094-7726)
- Hideki Nagata (ORCID: https://orcid.org/0000-0002-9928-7245)
- Takashi Kanou (ORCID: https://orcid.org/0000-0003-2955-1490)
- Meghan E. Kelly (ORCID: https://orcid.org/0009-0001-8092-8970)
- Carl Atkinson (ORCID: https://orcid.org/0000-0002-0067-0210)
- Yasushi Shintani (ORCID: https://orcid.org/0000-0002-2540-5288)
- Takahide Toyoda (ORCID: https://orcid.org/0000-0003-4766-5221)
- Yudai Miyashita (ORCID: https://orcid.org/0000-0001-8959-3823)
- Alicia Steffens (ORCID: https://orcid.org/0009-0005-7762-4772)
- Kaijie Zhang (ORCID: https://orcid.org/0000-0003-3674-0740)
- Tōru Kimura (ORCID: https://orcid.org/0000-0003-4504-232X)
- Bowen Wang (ORCID: https://orcid.org/0000-0003-1378-6594)
- Yusuke Sugiura (ORCID: https://orcid.org/0009-0004-7326-8419)
Institutions
- Northwestern University (US)
- Osaka City University (JP)
- Northwestern Medicine (US)
- The University of Osaka (JP)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1183/13993003.01738-2025
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.05