Emergence of High-Level Azithromycin Resistance in Neisseria gonorrhoeae: Genomic Insights from a Nine-Year (2016-2024) Study from North India
A nine-year retrospective study from a North Indian STI reference centre observed 10% (5/50) azithromycin-resistant gonococcal isolates, including one HLR-AZM (MIC 256 μg/mL) strain. WGS of resistant isolates revealed 23S rRNA mutations (A2059G, C2611T, and C2597T), multiple resistance determinants, and MLST ST-7363/NG-STAR ST-6332 lineages, underscoring the need for continued molecular surveillance.
Authors
- Sana Afreen (ORCID: https://orcid.org/0000-0001-9701-2224)
- Nandita Sharma (ORCID: https://orcid.org/0009-0007-8943-9464)
- Karamjit Kaur
- M. S. Sethi
- Gurmeet Saini
- Ripamchisa Sangma
Institutions
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Sexually Transmitted Diseases
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1097/olq.0000000000002287
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00