Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes
We identified 9 significantly mutated genes, some of which are known drug targets. Among individual genes, only the BRAF p.V600E mutation was significantly associated with DS-survival, suggesting a limited survival impact from mutations driving colorectal cancer development.
Authors
- Tomotaka Ugai (ORCID: https://orcid.org/0000-0003-0182-5269)
- Ellen L. Goode (ORCID: https://orcid.org/0000-0002-9094-8326)
- Andrea Gsur (ORCID: https://orcid.org/0000-0002-9795-1528)
- Mingyang Song (ORCID: https://orcid.org/0000-0002-1324-0316)
- Bethany Van Guelpen (ORCID: https://orcid.org/0000-0002-9692-101X)
- Victor Moreno
- Christina C. Newton (ORCID: https://orcid.org/0000-0003-1471-5608)
- Jane C. Figueiredo (ORCID: https://orcid.org/0000-0002-2452-3194)
- Lisa A. Boardman (ORCID: https://orcid.org/0000-0002-1330-2054)
- David A. Drew (ORCID: https://orcid.org/0000-0003-0377-723X)
- Steven Gallinger
- Tabitha A. Harrison (ORCID: https://orcid.org/0000-0002-4173-7530)
- Michael Hoffmeister (ORCID: https://orcid.org/0000-0002-8307-3197)
- Claire Elizabeth Thomas (ORCID: https://orcid.org/0000-0001-9515-3277)
- Jeroen R. Huyghe (ORCID: https://orcid.org/0000-0001-6027-9806)
- Amanda Ewart Toland (ORCID: https://orcid.org/0000-0002-0271-1792)
- Marios Giannakis (ORCID: https://orcid.org/0000-0001-9012-6982)
- Robert S. Steinfelder (ORCID: https://orcid.org/0000-0003-4204-8013)
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- Peter T. Campbell (ORCID: https://orcid.org/0000-0002-5549-2036)
- Thomas J. Hudson (ORCID: https://orcid.org/0000-0002-1376-4849)
- Meredith A.J. Hullar (ORCID: https://orcid.org/0000-0002-5322-9568)
- Daniel D. Buchanan (ORCID: https://orcid.org/0000-0003-2225-6675)
- Kimberly F. Doheny (ORCID: https://orcid.org/0000-0001-8806-5738)
- Neil Murphy (ORCID: https://orcid.org/0000-0003-3347-8249)
- Tameka Shelford
- Stephen B. Gruber (ORCID: https://orcid.org/0000-0001-8656-7822)
- Quang M. Trinh (ORCID: https://orcid.org/0000-0002-3602-2290)
- Elom K. Aglago (ORCID: https://orcid.org/0000-0002-0442-3284)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Mireia Obón‐Santacana (ORCID: https://orcid.org/0000-0003-4646-3513)
- Polly A. Newcomb
- Peter Georgeson (ORCID: https://orcid.org/0000-0002-5096-4735)
- Amy J. French
- Wei Sun (ORCID: https://orcid.org/0000-0002-6350-1107)
- Annette Peters (ORCID: https://orcid.org/0000-0001-6645-0985)
- Conghui Qu (ORCID: https://orcid.org/0000-0003-1927-6245)
- Sophia Harlid (ORCID: https://orcid.org/0000-0001-8540-6891)
- Caroline Y. Um (ORCID: https://orcid.org/0000-0001-5449-6230)
- Mark A. Jenkins (ORCID: https://orcid.org/0000-0002-8964-6160)
- Li Yang Hsu (ORCID: https://orcid.org/0000-0002-0396-066X)
- Stephen J. Chanock (ORCID: https://orcid.org/0000-0002-2324-3393)
- Wen‐Yi Huang
- Syed Hassan Ejaz Zaidi
- Amanda I. Phipps (ORCID: https://orcid.org/0009-0002-4864-8351)
- H. Yin (ORCID: https://orcid.org/0000-0001-6977-8257)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Shuji Ogino
- Yi Lin
- Sonja Berndt
Institutions
- Broad Institute (US)
- Ontario Institute for Cancer Research (CA)
- University of Southern California (US)
- Cedars-Sinai Medical Center (US)
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Mount Sinai Hospital (CA)
- National Institutes of Health (US)
- Barnes-Jewish Hospital (US)
- Albert Einstein College of Medicine (US)
- City Of Hope National Medical Center (US)
- The Royal Melbourne Hospital (AU)
- Mayo Clinic (US)
- Harvard University (US)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- German Cancer Research Center (DE)
- University of Toronto (CA)
- University of Washington (US)
- Washington University in St. Louis (US)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Heidelberg University (DE)
- Johns Hopkins Medicine (US)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Comprehensive Cancer Center Vienna (AT)
- Jewish Hospital (US)
- Institut Català d'Oncologia (ES)
- National Center for Tumor Diseases (DE)
- Dana-Farber Cancer Institute (US)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Centre international de recherche sur le cancer (FR)
- Imperial College London (GB)
- The Ohio State University (US)
- Medical University of Vienna (AT)
- Umeå University (SE)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s12885-025-15440-x
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00