Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes

We identified 9 significantly mutated genes, some of which are known drug targets. Among individual genes, only the BRAF p.V600E mutation was significantly associated with DS-survival, suggesting a limited survival impact from mutations driving colorectal cancer development.

Authors

Institutions

Publication Details

Journal
BMC Cancer
Published
2025-12-18
DOI
https://doi.org/10.1186/s12885-025-15440-x
Primary Topic
Colorectal Cancer Treatments and Studies
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes

Tomotaka Ugai, Ellen L. Goode, Andrea Gsur, Mingyang Song et al.
BMC Cancer
Colorectal Cancer Treatments and Studies
article

Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes

Tomotaka Ugai, Ellen L. Goode, Andrea Gsur, Mingyang Song, Bethany Van Guelpen, Victor Moreno, Christina C. Newton, Jane C. Figueiredo, Lisa A. Boardman, David A. Drew, Steven Gallinger, Tabitha A. Harrison, Michael Hoffmeister, Claire Elizabeth Thomas, Jeroen R. Huyghe, Amanda Ewart Toland, Marios Giannakis, Robert S. Steinfelder, Jonathan Andrew Nowak, Peter T. Campbell, Thomas J. Hudson, Meredith A.J. Hullar, Daniel D. Buchanan, Kimberly F. Doheny, Neil Murphy, Tameka Shelford, Stephen B. Gruber, Quang M. Trinh, Elom K. Aglago, Marc J. Gunter, Hermann Brenner, Mireia Obón‐Santacana, Polly A. Newcomb, Peter Georgeson, Amy J. French, Wei Sun, Annette Peters, Conghui Qu, Sophia Harlid, Caroline Y. Um, Mark A. Jenkins, Li Yang Hsu, Stephen J. Chanock, Wen‐Yi Huang, Syed Hassan Ejaz Zaidi, Amanda I. Phipps, H. Yin, Andrew T. Chan, Shuji Ogino, Yi Lin, Sonja Berndt
article en

Abstract

We identified 9 significantly mutated genes, some of which are known drug targets. Among individual genes, only the BRAF p.V600E mutation was significantly associated with DS-survival, suggesting a limited survival impact from mutations driving colorectal cancer development.

BMC CancerVol. 26(1)
Broad Institute (US), Ontario Institute for Cancer Research (CA), University of Southern California (US), Cedars-Sinai Medical Center (US), Brigham and Women's Hospital (US), American Cancer Society (US), Mount Sinai Hospital (CA), National Institutes of Health (US), Barnes-Jewish Hospital (US), Albert Einstein College of Medicine (US), City Of Hope National Medical Center (US), The Royal Melbourne Hospital (AU), Mayo Clinic (US), Harvard University (US), Johns Hopkins University (US), The University of Melbourne (AU), German Cancer Research Center (DE), University of Toronto (CA), University of Washington (US), Washington University in St. Louis (US), Lunenfeld-Tanenbaum Research Institute (CA), Heidelberg University (DE), Johns Hopkins Medicine (US), Institut d'Investigació Biomédica de Bellvitge (ES), Massachusetts General Hospital (US), Fred Hutch Cancer Center (US), Comprehensive Cancer Center Vienna (AT), Jewish Hospital (US), Institut Català d'Oncologia (ES), National Center for Tumor Diseases (DE), Dana-Farber Cancer Institute (US), National Cancer Institute (US), Mayo Clinic in Florida (US), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Centre international de recherche sur le cancer (FR), Imperial College London (GB), The Ohio State University (US), Medical University of Vienna (AT), Umeå University (SE)
Openalex Percentile: Top 43%
Colorectal Cancer Treatments and Studies
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.