Longitudinal Fecal Short-Chain Fatty Acid Trajectories in Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study
In this pilot cohort of preterm infants, EONS was associated with early, structured alterations in fecal SCFA profiles, characterized by reduced acetic-acid dominance and relative enrichment of non-acetate acids. Dynamic, ratio-based assessment proved more informative than absolute concentrations alone, revealing transient intestinal metabolic signatures accompanying systemic infection. These findings provide the first longitudinal evidence of gut metabolic involvement in EONS and lay the groundwork for larger, multi-center studies integrating SCFA trajectories with microbiome and immune profiling to refine early risk stratification for systemic infection in high-risk neonatal populations.
Authors
- A.A. Lenyushkina (ORCID: https://orcid.org/0000-0001-8929-2991)
- O.A. Krogh-Jensen (ORCID: https://orcid.org/0000-0002-5178-5659)
- Г. Т. Сухих (ORCID: https://orcid.org/0000-0002-7712-1260)
- Alisa Tokareva (ORCID: https://orcid.org/0000-0001-5918-9045)
- Франкевич Владимир Евгеньевич (ORCID: https://orcid.org/0000-0002-9780-4579)
- Natalia Starodubtseva (ORCID: https://orcid.org/0000-0001-6650-5915)
- I.V. Nikitina (ORCID: https://orcid.org/0000-0002-1103-1908)
- Evgenii Kukaev (ORCID: https://orcid.org/0000-0002-8397-3574)
Institutions
- Sechenov University (RU)
- Siberian State Medical University (RU)
- Semenov Institute of Chemical Physics (RU)
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation (RU)
- Scientific Center of Children's Health (RU)
Publication Details
- Journal
- Life
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3390/life15121943
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00