LIG1 overexpression enhances DNA repair and immune escape leading to poor prognosis in osteosarcoma
LIG1 drives OS progression and immune evasion by remodeling the tumor microenvironment. It serves as an independent prognostic biomarker and a potential therapeutic target, particularly in combination with immune checkpoint blockade.
Authors
- Gusheng Tang (ORCID: https://orcid.org/0000-0002-2682-0985)
- Yu Tang
- Peng Yan (ORCID: https://orcid.org/0000-0003-2930-7447)
- Qiangqiang Wang (ORCID: https://orcid.org/0000-0002-5506-6539)
- Wenju Fu
Institutions
- Shandong University of Aeronautics (CN)
- Nantong University (CN)
- Taizhou Second People's Hospital (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s40001-025-03647-4
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00