Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model
Our findings suggest that sex differences are observed in influenza vaccine-induced immunity and protection during obesity, where males are more severely affected. These findings highlight the importance of considering biological sex and obesity status in influenza vaccine design and testing.
Authors
- Saurav Pantha (ORCID: https://orcid.org/0000-0002-8847-1928)
- Santosh Dhakal (ORCID: https://orcid.org/0000-0002-4494-8608)
- Tawfik Aboellail (ORCID: https://orcid.org/0000-0003-0989-5333)
- Brian Wolfe
- Swapnil Magar (ORCID: https://orcid.org/0009-0006-0458-165X)
- Saranya Vijayakumar
Institutions
- Kansas State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1699275
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Johns Hopkins University
- King Saud University
- Johns Hopkins Bloomberg School of Public Health
- National Institute of General Medical Sciences