Glutaredoxin 2 Protects Lens Epithelial Cells From Ferroptosis by Preventing HNRNPA2B1 S-Glutathionylation in Diabetes-Mediated Cataractogenesis
Grx2 exerts protective effects against ferroptosis in diabetes-mediated cataractogenesis by inhibiting HNRNPA2B1 S-glutathionylation and modulating PTEN/AKT signaling pathway.
Authors
- Chenshuang Li (ORCID: https://orcid.org/0000-0001-6331-6983)
- Xinnan Li (ORCID: https://orcid.org/0000-0001-7411-1190)
- Xi Chen (ORCID: https://orcid.org/0000-0002-8911-4172)
- Liang Chen
- Hong Yan (ORCID: https://orcid.org/0000-0001-7521-1636)
- Siqi Zhang (ORCID: https://orcid.org/0000-0002-9815-4395)
- Zaoxia Guo
- Chenjun Guo
Institutions
- Shaanxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1167/iovs.66.15.58
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00