Extracellular Matrix Stiffness Regulates Cancer Stemness in Uveal Melanoma via the PIEZO1–DOT1L Axis
The PIEZO1-DOT1L axis mediated ECM stiffness-driven stemness and tumor progression in UM. Targeting this mechanotransduction pathway by modulating ECM stiffness or its downstream effectors may provide a novel therapeutic strategy for UM.
Authors
- Jinsong Zhao (ORCID: https://orcid.org/0000-0002-6801-2169)
- Yuanqiang Zhang (ORCID: https://orcid.org/0000-0002-4592-4966)
- Jinrong Cui (ORCID: https://orcid.org/0000-0003-1063-7876)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-9825-4110)
- Songtao Wang (ORCID: https://orcid.org/0000-0003-1463-6897)
- Jinfeng Cao (ORCID: https://orcid.org/0000-0001-8826-311X)
Institutions
- Second Affiliated Hospital of Jilin University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1167/iovs.66.15.57
- Citations
- 1
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.16