Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression
This work overturns the longstanding paradigm that ITGB2 is restricted to leukocytes by discovering a tumor cell-intrinsic ITGB2:ICAM-1:Wnt protumorigenic axis as a bona fide cancer therapeutic target in melanoma.
Authors
- Jennifer Landsberg (ORCID: https://orcid.org/0000-0001-8029-3883)
- Christina Martins (ORCID: https://orcid.org/0000-0002-9160-1017)
- Laure Migayron (ORCID: https://orcid.org/0000-0003-2003-1923)
- Gëorge F. Murphy (ORCID: https://orcid.org/0000-0001-9362-5146)
- Julia M. Martínez-Gómez
- Mitchell Paul Levesque (ORCID: https://orcid.org/0000-0001-5902-9420)
- Steven R. Barthel (ORCID: https://orcid.org/0000-0003-2107-4570)
- Emma L. Berdan (ORCID: https://orcid.org/0000-0002-6435-4604)
- Emrullah Birgin (ORCID: https://orcid.org/0000-0002-0338-3727)
- Nuh N. Rahbari (ORCID: https://orcid.org/0000-0002-4703-9039)
- Erik Rasbach (ORCID: https://orcid.org/0000-0002-0807-3058)
- Tobias Schatton (ORCID: https://orcid.org/0000-0003-1386-680X)
- Ali Kassem (ORCID: https://orcid.org/0000-0002-1820-8518)
- Shuyun Xu (ORCID: https://orcid.org/0000-0003-2762-4772)
- Kyla Mucciarone (ORCID: https://orcid.org/0000-0003-3755-2370)
- Julia Holzgruber (ORCID: https://orcid.org/0000-0002-7804-9387)
- Anne Brandenburg (ORCID: https://orcid.org/0000-0002-8409-7174)
- Christine G. Lian (ORCID: https://orcid.org/0000-0003-4626-1612)
- Reinhard Dummer (ORCID: https://orcid.org/0000-0002-2279-6906)
- Yuejun Zhen (ORCID: https://orcid.org/0000-0002-0162-5665)
- Thomas S. Kupper (ORCID: https://orcid.org/0000-0002-4229-2916)
- Zsófi Kulcsár
- Anastasia Iris Karkempetzaki
- Mariana Silva (ORCID: https://orcid.org/0009-0002-8546-4164)
- Nayoung Lee (ORCID: https://orcid.org/0000-0002-1594-267X)
- Praveen Singh
- Jason B. Williams (ORCID: https://orcid.org/0000-0001-7123-6940)
- Shannan Ho Sui
- Jessica Riopedre
- Nadine Suessner
Institutions
- Johannes Kepler University of Linz (AT)
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Universität Ulm (DE)
- University Hospital Bonn (DE)
- University Hospital of Zurich (CH)
- Cancer Research And Biostatistics (US)
- University Hospital Ulm (DE)
- Technische Hochschule Ulm (DE)
- New York University (US)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s12943-025-02527-z
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00