Prodromal Peripheral Immune Cell Profile in Drug‐Induced Parkinsonism Relative to Parkinson's Disease

The elevated neutrophil counts in DIP and PD suggest a shared innate immune system involvement. However, in DIP, the peripheral immune changes appear driven by psychiatric comorbidities, whereas lymphopenia may represent a distinctive prodromal biomarker of PD.

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Publication Details

Journal
Movement Disorders Clinical Practice
Published
2025-12-18
DOI
https://doi.org/10.1002/mdc3.70476
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Prodromal Peripheral Immune Cell Profile in Drug‐Induced Parkinsonism Relative to Parkinson's Disease

Joseph H. Friedman, Saud Alhusaini, Varun Kasibhatla, M E Mawad et al.
Movement Disorders Clinical Practice
Parkinson's Disease Mechanisms and Treatments
article

Prodromal Peripheral Immune Cell Profile in Drug‐Induced Parkinsonism Relative to Parkinson's Disease

Joseph H. Friedman, Saud Alhusaini, Varun Kasibhatla, M E Mawad, B Lien, Jenee Anekwe
article en

Abstract

The elevated neutrophil counts in DIP and PD suggest a shared innate immune system involvement. However, in DIP, the peripheral immune changes appear driven by psychiatric comorbidities, whereas lymphopenia may represent a distinctive prodromal biomarker of PD.

Movement Disorders Clinical Practice
Brown University (US), Rhode Island Hospital (US), Butler Hospital (US)
Openalex Percentile: Top 44%
Parkinson's Disease Mechanisms and Treatments
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