ALDH3A2 targets arachidonic acid to promote cell metastasis in TNBC via AMPK/m-TOR signaling pathway
Our work establishes ALDH3A2 as a pivotal regulator of lipid metabolic reprogramming in TNBC metastasis, providing mechanistic insights into AA-mediated tumor progression. These findings position ALDH3A2 as a promising therapeutic target and prognostic biomarker for TNBC management.
Authors
- Doudou Wen
- Shubing Zhang (ORCID: https://orcid.org/0000-0003-2819-8023)
- Xiaotang Di (ORCID: https://orcid.org/0000-0002-7350-8978)
- Keli Xu (ORCID: https://orcid.org/0000-0001-5535-1076)
- Suxia Luo (ORCID: https://orcid.org/0000-0002-8639-7314)
- Hao Jiang (ORCID: https://orcid.org/0000-0001-7270-1939)
- Rongji Yu
- Ding Wang
Institutions
- Central South University (CN)
- Hunan University (CN)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s13058-025-02135-1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00