Differential Left and Right Carotid Artery Blood Flow and Altered Hippocampal Mitochondrial Function After Transverse Aortic Constriction in Aging Rats
Although both limited and pulsatile blood flow alter mitochondrial fusion markers, only pulsatile flow impairs mitochondrial respiration, suggesting turbulent hemodynamics may drive metabolic dysfunction in vascular dementia.
Authors
- Gabriel S. Pena (ORCID: https://orcid.org/0000-0003-4151-1141)
- Sarah Kuzmiak‐Glancy (ORCID: https://orcid.org/0000-0002-2196-6643)
- Sushant M. Ranadive (ORCID: https://orcid.org/0000-0003-1674-4285)
- Yuan Liu (ORCID: https://orcid.org/0000-0003-1420-0276)
- J. Carson Smith
- Maria Canellas Da Silva (ORCID: https://orcid.org/0009-0000-3287-0578)
Institutions
- University of Maryland, College Park (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1161/jaha.125.041233
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00