Systematic review of antimicrobial pharmacokinetic/pharmacodynamic indices in murine thigh and hollow fibre dose fractionation studies analysed with a standard method
This study suggests a standard method for PKPD index model selection and provides a database on PKPD index analysis. Building the Emax model from one to four estimated parameters and assessing them with AIC is recommended to avoid over fitting. Too few HFIM dose fractionation studies were found to allow comparison of PKPD index with MTIM.
Authors
- Mona Bajaj‐Elliott (ORCID: https://orcid.org/0000-0002-5234-576X)
- Stefano Azzariti (ORCID: https://orcid.org/0009-0007-9293-5266)
- John Readman
- Najla Alabdulkarim (ORCID: https://orcid.org/0000-0002-5887-8583)
- Japhette Esther Kembou-Ringert (ORCID: https://orcid.org/0000-0002-9612-7799)
- Andrew Mead (ORCID: https://orcid.org/0000-0003-3550-3030)
- Robert Oakley (ORCID: https://orcid.org/0000-0001-6329-8658)
- Joseph Frank Standing (ORCID: https://orcid.org/0000-0002-4561-7173)
- Mario Cortina‐Borja (ORCID: https://orcid.org/0000-0003-0627-2624)
- Suzanne A M Wenker
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Leiden University (NL)
- Royal Veterinary College (GB)
- University of Applied Sciences Leiden (NL)
- Leiden University Medical Center (NL)
- Great Ormond Street Hospital (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- European Society of Clinical Microbiology and Infectious Diseases (CH)
- University College London (GB)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1093/jac/dkaf446
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00