Atherosclerotic progression at sites of low shear stress is attenuated by myeloid-PlexinD1 deficiency through suppression of classical macrophage polarization

OSS drives atherosclerotic progression by suppressing endothelial PTGS2/PGE2 to promote PlexinD1/NF-κB-mediated M1 macrophage polarization. PlexinD1 represents a promising target to identify and stabilize atherosclerotic lesions.

Authors

Yingqian Zhang (ORCID: https://orcid.org/0000-0002-1208-6070)
Xin Ran (ORCID: https://orcid.org/0000-0001-8833-9006)
Lei Gao (ORCID: https://orcid.org/0000-0003-1476-1460)
Mingyi Wang (ORCID: https://orcid.org/0000-0001-6412-369X)
Ziqian Wang (ORCID: https://orcid.org/0000-0002-6996-4356)
Chen Zhang (ORCID: https://orcid.org/0000-0001-6304-9360)
Liangliang Liu (ORCID: https://orcid.org/0000-0002-6863-9869)
Hui Hui (ORCID: https://orcid.org/0000-0002-6732-4232)
Yundai Chen (ORCID: https://orcid.org/0000-0003-4409-9375)
Zeyu Sun
Mingrui Ma (ORCID: https://orcid.org/0000-0003-1304-278X)
Jie Tian

Institutions

Nankai University (CN)
Chinese PLA General Hospital (CN)
Shandong Institute of Automation (CN)
Beihang University (CN)

Publication Details

Journal: European Heart Journal
Published: 2025-11-21
DOI: https://doi.org/10.1093/eurheartj/ehaf991
Citations: 1
Primary Topic: Immune cells in cancer
Type: article
Field-Weighted Citation Impact: 0.80

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article

Atherosclerotic progression at sites of low shear stress is attenuated by myeloid-PlexinD1 deficiency through suppression of classical macrophage polarization

Yingqian Zhang, Xin Ran, Lei Gao, Mingyi Wang et al.

Nov 21, 2025

1 citations

European Heart Journal

Immune cells in cancer

0.80

article

Atherosclerotic progression at sites of low shear stress is attenuated by myeloid-PlexinD1 deficiency through suppression of classical macrophage polarization

Yingqian Zhang, Xin Ran, Lei Gao, Mingyi Wang, Ziqian Wang, Chen Zhang, Liangliang Liu, Hui Hui, Yundai Chen, Zeyu Sun, Mingrui Ma, Jie Tian

November 21, 2025article en

1 citations

Abstract

OSS drives atherosclerotic progression by suppressing endothelial PTGS2/PGE2 to promote PlexinD1/NF-κB-mediated M1 macrophage polarization. PlexinD1 represents a promising target to identify and stabilize atherosclerotic lesions.

European Heart JournalVol. 47(10)

Nankai University (CN), Chinese PLA General Hospital (CN), Shandong Institute of Automation (CN), Beihang University (CN)

Openalex Percentile: Top 21%

Immune cells in cancer

0.80

DOI Source OpenAlex

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Atherosclerotic progression at sites of low shear stress is attenuated by myeloid-PlexinD1 deficiency through suppression of classical macrophage polarization — Yingqian Zhang, Xin Ran, et al. · European Heart Journal (2025) | TGRS Research Map | TGRS