Shared genetic architecture between anorexia nervosa and metabolomic biomarkers suggest underlying causal pathways
Our findings point to strong associations between AN and metabolomic markers, opposite in direction to anthropometric and cardiometabolic traits. Our results suggest a mediating role for BMI and implicate developmental and lipid-based biological processes with a bidirectional causal relationship. The findings offer a novel perspective on the etiology of AN and suggest opportunities for targeting specific metabolomic biomarkers in weight restoration approaches.
Authors
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Alexey A. Shadrin (ORCID: https://orcid.org/0000-0002-7467-250X)
- Carolina Makowski (ORCID: https://orcid.org/0000-0002-8816-4549)
- Anders M. Dale
Institutions
- Oslo University Hospital (NO)
- J. Craig Venter Institute (US)
- Norwegian Institute of Public Health (NO)
- University of Oslo (NO)
- University of California San Diego (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-05
- DOI
- https://doi.org/10.64898/2025.11.29.25341234
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Universitetet i Oslo
- Norges Forskningsråd
- National Institutes of Health
- National Institute of Mental Health