Biopsy and Blood Gene Expression Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients
Molecular profiling of tissue and blood reflects distinct but complementary aspects of transplant biology and confirms that subAR and cAR share overlapping molecular profiles, supporting the hypothesis that subAR represents an early stage in the progression toward clinical rejection. These findings highlight the limitations of relying solely on histological evaluation and support the use of molecular tissue profiling as an adjunct to histology, particularly in diagnostically ambiguous cases. Molecular profiling provides a supporting framework for identifying subclinical rejection and guiding personalized immunosuppression to improve long-term outcomes.
Authors
- Christabel Rebello
- John J. Friedewald (ORCID: https://orcid.org/0000-0002-9344-9928)
- Sunil M. Kurian (ORCID: https://orcid.org/0000-0002-7782-7263)
- Emilio D. Poggio (ORCID: https://orcid.org/0000-0003-1492-5103)
- Christopher L. Marsh (ORCID: https://orcid.org/0000-0002-6517-076X)
- Michaël Abécassis (ORCID: https://orcid.org/0000-0001-9333-463X)
- Raymond L. Heilman (ORCID: https://orcid.org/0000-0003-0367-2008)
- Sook Hyeon Park
Institutions
- Northwestern University (US)
- Scripps Health (US)
- Cleveland Clinic (US)
- University of Arizona (US)
- Scripps Green Hospital (US)
- Mayo Clinic Hospital (US)
- Scripps Clinic (US)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1097/txd.0000000000001892
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi
- Northwestern University
- CSL Behring
- CareDx
- National Institutes of Health