Recurrent <i>CACNA1H</i> E282K is a gain-of-function mutation associated with primary hyperaldosteronism
Our study suggests that Cav3.2E282K is a gain-of-function mutation and T-type calcium channel blockers may be efficient in controlling aldosterone levels for PA patients carrying mutant Cav3.2.
Authors
- Qiujing Chen (ORCID: https://orcid.org/0000-0002-5668-3774)
- Aifang Nie
- Rulai Han
- Tingwei Su (ORCID: https://orcid.org/0000-0001-6472-3492)
- Lei Ye (ORCID: https://orcid.org/0000-0003-4064-4460)
- Weiqing Wang (ORCID: https://orcid.org/0000-0001-6027-3084)
- Cui Zhang (ORCID: https://orcid.org/0000-0002-1847-9991)
- Lei Jiang (ORCID: https://orcid.org/0009-0001-8623-0098)
- Xu Zhong (ORCID: https://orcid.org/0000-0002-2175-3437)
- Yiran Jiang (ORCID: https://orcid.org/0000-0003-2078-8125)
- Yaxue Zhao (ORCID: https://orcid.org/0000-0002-5963-9779)
- Luming Wu
- Weiwei Zhou (ORCID: https://orcid.org/0000-0003-2003-7743)
- Ruyi Li (ORCID: https://orcid.org/0009-0000-2379-5537)
- Kim P. Lu (ORCID: https://orcid.org/0009-0006-5784-1304)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/ejendo/lvaf253
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00