Sevoflurane Exposure Exacerbates Memory Impairment and Pathological Manifestation by Inhibiting <scp>AKT</scp> /m <scp>TOR</scp> ‐Mediated Autophagy in <scp>P</scp> 301 <scp>L</scp> Tau Transgenic Mice
These findings suggest that autophagy signaling appears to be a promising target for intervention in sevoflurane-induced cognitive impairment in the early tau pathology, which lays the foundation for further study of the underlying mechanisms.
Authors
- Xifei Yang (ORCID: https://orcid.org/0000-0002-9000-7016)
- Zhongliang Dai (ORCID: https://orcid.org/0000-0003-4641-0825)
- Wei Xiong (ORCID: https://orcid.org/0000-0003-2624-6474)
- Youzhi Li (ORCID: https://orcid.org/0000-0003-3250-9314)
- Wenli Gao (ORCID: https://orcid.org/0000-0002-2468-9805)
- Kaiwu He (ORCID: https://orcid.org/0000-0002-8131-5850)
- Zhijing Zhang (ORCID: https://orcid.org/0000-0002-3769-569X)
- Wei Kong (ORCID: https://orcid.org/0000-0002-7965-4407)
- Lixin Chen (ORCID: https://orcid.org/0000-0003-1679-7686)
- Yanmei Xing
Institutions
- Jinan University (CN)
- Guangdong Medical College (CN)
- Southern University of Science and Technology (CN)
- Key Laboratory of Guangdong Province (CN)
- Shenzhen Center for Disease Control and Prevention (CN)
- Dongguan People’s Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cns.70694
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Sanming Project of Medicine in Shenzhen