Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan disease

MPO is increased in MFS and contributes to thoracic aortic dilatation by inducing inflammatory endothelial activation, oxidative stress, and adverse extracellular matrix remodelling. Pharmacological and genetic inhibition of MPO reduced MFS-related aortic dilation in mice, highlighting MPO as a promising therapeutic target in MFS.

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Publication Details

Journal
Cardiovascular Research
Published
2025-11-26
DOI
https://doi.org/10.1093/cvr/cvaf248
Primary Topic
Aortic Disease and Treatment Approaches
Type
article
Field-Weighted Citation Impact
0.00
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article

Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan disease

Holger Winkels, Zsuzsanna Wolf, Vivian de Waard, Norbert Gerdes et al.
Cardiovascular Research
Aortic Disease and Treatment Approaches
article

Myeloperoxidase aggravates thoracic aortic aneurysm formation in Marfan disease

Holger Winkels, Zsuzsanna Wolf, Vivian de Waard, Norbert Gerdes, Marie‐Lisa Eich, Birgid Schömig‐Markiefka, Simon Braumann, Laura‐Marie A. Zimmermann, Gerhard Sengle, Susanne Pfeiler, Suchitra Narayan, Harshal Nemade, Benedicta Quaye Mensah, Sébastian Lechner, Simon Geißen, Maysam Ahdab, Felix Sebastian Nettersheim, Christina Diekmann, Gisela Teixidó‐Turà, Stefan Holdenrieder, Andrea Guala, Juan Miguel Redondo, Andrea de la Fuente‐Alonso, Dennis Mehrkens, Martin Mollenhauer, Alexander Hof, Miguel R. Campanero, Patrik Schelemei, Arnout Mieremet, Johannes Dohr, Ulrich Flögel, Daniela Wenzel, Felix Ballmann, Bernd K. Fleischmann, Stephan Baldus, Alexander Brückner, J. Francisco Nistal, Henning Guthoff, Wiebke Kreuzberg, Jil Bastigkeit, Felix S.R. Picard, Mitzi van Andel, Malte Kochen, Lauren De Vore, Matti Adam, Maarten Groenink, Per Arkenberg, Anna Klinke, Harald Kaemmerer, Artur Evangelista, Anna Rappenecker, Cedric Fitsch
article en

Abstract

MPO is increased in MFS and contributes to thoracic aortic dilatation by inducing inflammatory endothelial activation, oxidative stress, and adverse extracellular matrix remodelling. Pharmacological and genetic inhibition of MPO reduced MFS-related aortic dilation in mice, highlighting MPO as a promising therapeutic target in MFS.

Cardiovascular ResearchVol. 122(2)
Universidad de Cantabria (ES), University of Cologne (DE), Heart and Diabetes Center North Rhine-Westphalia (DE), Düsseldorf University Hospital (DE), Centro de Investigación en Red en Enfermedades Cardiovasculares (ES), Vall d'Hebron Institut de Recerca (ES), Amsterdam Neuroscience (NL), Instituto de Investigación Marqués de Valdecilla (ES), Centro de Investigación Biomédica en Red (ES), Spanish National Centre for Cardiovascular Research (ES), Centro de Biología Molecular Severo Ochoa (ES), Deutsches Herzzentrum München (DE), Amsterdam University Medical Centers (NL), University Hospital Cologne (DE), Life & Brain (Germany) (DE), Heinrich Heine University Düsseldorf (DE), Universidad Autónoma de Madrid (ES), University of Amsterdam (NL)
Openalex Percentile: Top 40%
Aortic Disease and Treatment Approaches
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