<i>In vitro</i> selection of cefiderocol-resistant mutants in <i>Acinetobacter baumannii</i> harbouring the most common carbapenemase genes
Global regulators BfmS and OxyR were responsible for decreasing the expression of piuA and pirA genes, thereby contributing to cefiderocol resistance. This evolutionary analysis enhances our understanding of the mechanisms underlying cefiderocol resistance and identifies potential molecular targets for the development of new therapeutics against CRAB.
Authors
- Jacqueline Findlay (ORCID: https://orcid.org/0000-0002-7335-9001)
- Jean‐Winoc Decousser (ORCID: https://orcid.org/0000-0001-7105-6202)
- Patrice Nordmann (ORCID: https://orcid.org/0000-0002-1343-1622)
- Otávio Hallal Ferreira Raro (ORCID: https://orcid.org/0000-0001-7374-0788)
- Laurent Poirel (ORCID: https://orcid.org/0000-0001-5160-5286)
Institutions
- University of Fribourg (CH)
- Université Paris-Est Créteil (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1093/jac/dkaf462
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00