Genomics of Acute Myeloid Leukemia at Diagnosis and Remission
Acute myeloid leukemia is a diagnostic category encompassing multiple rare hematological malignances. We show, in this nationwide multicenter study, that standardized unbiased whole genome DNA-sequencing and disease-optimized bioinformatics can replicate conventional "standard of care" AML clinical testing results, while also revealing currently underdiagnosed AML disease biology and potential genetic predisposition.
Authors
- Pratheesh Sathyan
- Lori S. Muffly (ORCID: https://orcid.org/0000-0002-9887-6136)
- Melhem Solh (ORCID: https://orcid.org/0000-0003-3766-5623)
- Sandeep Gurbuxani (ORCID: https://orcid.org/0000-0003-0716-8730)
- Steven M. Devine (ORCID: https://orcid.org/0000-0001-7731-759X)
- James Han (ORCID: https://orcid.org/0009-0002-0333-7568)
- Hetty E. Carraway (ORCID: https://orcid.org/0000-0001-5241-3614)
- Vidya Kudlingar
- Michael W. Drazer (ORCID: https://orcid.org/0000-0002-8171-4106)
- Jiguang Guo (ORCID: https://orcid.org/0000-0002-5357-0029)
- Christina K. Ferrone (ORCID: https://orcid.org/0000-0001-9309-2132)
- Rahul S. Vedula (ORCID: https://orcid.org/0000-0003-0486-3981)
- Farah Sahoo
- Hanjoong Jo (ORCID: https://orcid.org/0000-0003-1833-372X)
- Yi‐Bin Chen (ORCID: https://orcid.org/0000-0002-9554-1058)
- Reena Jayani (ORCID: https://orcid.org/0000-0002-5291-5945)
- Sam Ng (ORCID: https://orcid.org/0000-0001-7232-319X)
- Severine Catreux (ORCID: https://orcid.org/0009-0008-1813-1240)
- Michael R. Grunwald (ORCID: https://orcid.org/0000-0001-5407-9875)
- Stephanie Bo‐Subait
- Jesse M. Tettero (ORCID: https://orcid.org/0000-0002-0811-0824)
- Sophia Balderman (ORCID: https://orcid.org/0000-0001-8157-8725)
- Stephanie Waldvogel
- Gege Gui (ORCID: https://orcid.org/0000-0002-4141-183X)
- Laura W. Dillon
- Jamie Diemer
- Elizabeth A. Griffiths (ORCID: https://orcid.org/0000-0002-0288-8248)
- Alexandra Gomez-Arteaga (ORCID: https://orcid.org/0000-0003-0897-3790)
- Christopher Simon Hourigan (ORCID: https://orcid.org/0000-0002-6189-8067)
- Yutong Qiu (ORCID: https://orcid.org/0000-0001-6058-1212)
- Lawrence J. Druhan (ORCID: https://orcid.org/0000-0002-2019-2252)
- Brian C. Shaffer (ORCID: https://orcid.org/0000-0003-3433-9179)
- Cecilia C.S. Yeung (ORCID: https://orcid.org/0000-0001-6799-2022)
- Stephen R. Spellman (ORCID: https://orcid.org/0000-0002-7271-8252)
- Amandeep Salhotra (ORCID: https://orcid.org/0000-0002-9302-5041)
- Nelli Bejanyan (ORCID: https://orcid.org/0000-0003-0194-7338)
- Khai Luong
- Jianqun Kou
- Elizabeth F. Krakow (ORCID: https://orcid.org/0000-0002-2690-3799)
- Melissa Yuwono Tjota (ORCID: https://orcid.org/0000-0002-5869-3175)
- Antonio Martin Jimenez-Jimenez
- Jean W. Bjerke
- Aaron C. Logan (ORCID: https://orcid.org/0000-0002-1179-5879)
- James S. Blachly (ORCID: https://orcid.org/0000-0002-4275-5562)
- Amir T. Fathi (ORCID: https://orcid.org/0000-0002-5848-6221)
- Emily Kolb
- Jeffery J. Auletta (ORCID: https://orcid.org/0000-0002-1515-2141)
- Wilfred W. Li (ORCID: https://orcid.org/0009-0007-1702-7196)
- Yunjiao Zhu (ORCID: https://orcid.org/0000-0003-3730-3374)
- Vanessa E. Kennedy (ORCID: https://orcid.org/0000-0002-1912-4076)
- Jason Hu (ORCID: https://orcid.org/0009-0008-7494-7340)
- Reem Bahr (ORCID: https://orcid.org/0009-0007-1608-712X)
- Sean Truong (ORCID: https://orcid.org/0009-0005-7584-2688)
- Kai Yu
- Jenny Vogel
- Mark T. Smith
- Rasha W Al-Ali
- Dylan Barfield
- Brenna K Tesch
- Bergetta Dietel
- Gabrielle Giammarino
- Danielle O'Donnell Vitali
- Syreeta Weatherspoon
- Allison J Getker (ORCID: https://orcid.org/0009-0001-3969-958X)
- Emily Heying Chihak (ORCID: https://orcid.org/0009-0003-9721-7248)
Institutions
- Northside Hospital (US)
- Roswell Park Comprehensive Cancer Center (US)
- National Institutes of Health (US)
- Cleveland Clinic (US)
- National Marrow Donor Program (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- Illumina (United States) (US)
- Cornell University (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Moffitt Cancer Center (US)
- University of Chicago (US)
- Fred Hutch Cancer Center (US)
- Institute of Cancer Research (CA)
- Presbyterian Hospital (US)
- European Society for Blood and Marrow Transplantation (NL)
- Levine Cancer Institute (US)
- City of Hope (US)
- Dana-Farber Cancer Institute (US)
- Cancer Research Center (US)
- Global Cancer Institute (US)
- Sylvester Comprehensive Cancer Center (US)
- Carilion Clinic (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-07
- DOI
- https://doi.org/10.64898/2025.12.04.25340141
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00