Role of NK cells in immune escape in patients with classical paroxysmal nocturnal haemoglobinuria
The quantity and function of NK cells in PNH patients are insufficient, in which CD59<sup>-</sup> NK cells have functional defects, whereas CD59<sup>+</sup> NK cells were mainly activated and potential involved in immune escape by regulation of T cells.
Authors
- Yingying Chen (ORCID: https://orcid.org/0000-0001-7575-0867)
- Zhaoyun Liu (ORCID: https://orcid.org/0000-0002-2730-1562)
- Mengting Che (ORCID: https://orcid.org/0009-0000-9262-5371)
- Chaomeng Wang (ORCID: https://orcid.org/0000-0002-6253-4169)
- Hui Liu (ORCID: https://orcid.org/0000-0002-1969-6015)
- Wei Qiang Wang (ORCID: https://orcid.org/0000-0002-1430-1360)
- Lijuan Li (ORCID: https://orcid.org/0000-0001-5984-1603)
- Honglei Wang (ORCID: https://orcid.org/0000-0002-1023-4826)
- Rong Fu (ORCID: https://orcid.org/0000-0002-9928-9224)
- Liyan Li (ORCID: https://orcid.org/0000-0003-2732-3646)
- Yan Yang (ORCID: https://orcid.org/0000-0002-9479-6817)
Institutions
- Tianjin Chengjian University (CN)
- Tianjin Medical University General Hospital (CN)
- ShanghaiTech University (CN)
- Tianjin People's Hospital (CN)
- State Key Laboratory of Chemical Engineering (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ctm2.70542
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00