Assessing neurobiology of lifelong premature ejaculation through brain MRI structural similarity gradient
We employed a novel approach, morphometric inverse divergence, to construct the brain structural similarity gradient. We provide evidence for abnormal structural similarity gradients in patients with LPE. We found an association between abnormal changes in gradients and clinical phenotypes, gene enrichment pathways, as well as neurotransmitter density.
Authors
- Lei Yan (ORCID: https://orcid.org/0000-0002-4669-8905)
- Jiaming Lu (ORCID: https://orcid.org/0009-0001-6888-8849)
- Qing Hu (ORCID: https://orcid.org/0000-0002-1041-1642)
- Xiaozhi Zhao (ORCID: https://orcid.org/0000-0002-4265-9730)
- Yutian Dai (ORCID: https://orcid.org/0000-0002-1459-8934)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-7592-1195)
- Cong Wang (ORCID: https://orcid.org/0000-0001-9383-1732)
- Qiming Deng (ORCID: https://orcid.org/0000-0001-9045-277X)
- Qingqiang Gao (ORCID: https://orcid.org/0009-0006-2252-6064)
Institutions
- Nanjing Drum Tower Hospital (CN)
- Vector Institute (CA)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s41747-025-00661-3
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Nanjing University