Human–environmental overlap of resistant Enterobacterales: genomic evidence linking coastal waters and community carriage of antimicrobial resistance in a low- and middle-income setting
Our findings indicate a shared resistance gene pool between human and environmental sources, characterized by bidirectional CRE exchange but dominated by an environment-to-human transmission pathway. This underscores the urgent need for effective wastewater treatment and improved sanitation practices to reduce human exposure and curb the spread of antibiotic resistance.
Authors
- Appiah Sarpong (ORCID: https://orcid.org/0000-0002-1828-9979)
- Appiah-Korang Labi (ORCID: https://orcid.org/0000-0001-7276-7057)
- Mary‐Magdalene Osei (ORCID: https://orcid.org/0000-0002-2216-7237)
- Noah Obeng‐Nkrumah (ORCID: https://orcid.org/0000-0002-1797-822X)
- Beverly Egyir
- Japheth A. Opintan (ORCID: https://orcid.org/0000-0003-3928-2116)
- Lady Asantewah Boamah Adomako (ORCID: https://orcid.org/0000-0002-9478-0057)
- Christian Owusu-Nyantakyi (ORCID: https://orcid.org/0009-0002-6285-0628)
- Rachel Ama Adadziwa Akorful
Institutions
- University of Ghana (GH)
- University of Health and Allied Sciences (GH)
- Noguchi Memorial Institute for Medical Research (GH)
- Council for Scientific and Industrial Research (GH)
Publication Details
- Journal
- Frontiers in Antibiotics
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/frabi.2025.1715797
- Primary Topic
- Pharmaceutical and Antibiotic Environmental Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Joint Programming Initiative on Antimicrobial Resistance
- University of Ghana