Clinical and Molecular Effect of the Anti– <scp>IL</scp> ‐18 Antibody Aletekitug in Adults With Atopic Dermatitis
A single 2 mg/kg IV dose of aletekitug was associated with improved outcomes at Week 12, which were sustained to Week 24, and modulated immune mechanisms beyond T2 inflammation. These results support IL-18 as a potential therapeutic target in moderate-to-severe AD.
Authors
- Naveen Prasad (ORCID: https://orcid.org/0000-0001-7248-4997)
- Parima Ghafoori
- Ester Del Duca (ORCID: https://orcid.org/0000-0001-7948-8536)
- Will Powley (ORCID: https://orcid.org/0000-0002-8515-2462)
- Chun‐Hang Tang (ORCID: https://orcid.org/0000-0002-3839-221X)
- Emma Guttman‐Yassky (ORCID: https://orcid.org/0000-0002-9363-324X)
- Zhenghong Li (ORCID: https://orcid.org/0000-0003-2583-5082)
- Swaroop Bose (ORCID: https://orcid.org/0000-0002-4337-9490)
- Marieta M. Ruseva
- Joanna Betts (ORCID: https://orcid.org/0000-0003-1729-1839)
- Eden David (ORCID: https://orcid.org/0000-0001-9666-4132)
- Léa Fortunato
- John Barnard (ORCID: https://orcid.org/0000-0001-8244-5879)
- Iain Uings (ORCID: https://orcid.org/0000-0001-8313-4685)
- Yeriel Estrada (ORCID: https://orcid.org/0000-0002-5172-6747)
- Hannah Wajdner
- Kiranmai Gumireddy
- Neda Shokrian
- Fiona Lovegrove (ORCID: https://orcid.org/0000-0001-6994-717X)
- Scott Van Buren (ORCID: https://orcid.org/0000-0002-5722-4342)
- Scott M. Dinehart (ORCID: https://orcid.org/0000-0002-6147-9604)
- Joanne Ellis (ORCID: https://orcid.org/0000-0001-7873-4571)
- Jenny Lowe (ORCID: https://orcid.org/0000-0002-8565-2723)
- Lawrence Charles Parish (ORCID: https://orcid.org/0000-0002-4612-1508)
- Joel Corrêa da Rosa (ORCID: https://orcid.org/0000-0003-4221-1976)
- Puneet Dhawan
- John B. Kelly (ORCID: https://orcid.org/0009-0007-5554-9358)
- John Edgar Browning (ORCID: https://orcid.org/0000-0002-8388-1493)
- Nicolas Wisniacki (ORCID: https://orcid.org/0000-0002-1681-9948)
- Gabriel K. Wong
- Wei Jing Loo
- Farhat Syed
- Núria Buil‐Bruna
Institutions
- Western University (CA)
- Thomas Jefferson University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Age UK (GB)
- Arkansas Cardiology (US)
- Mount Sinai Medical Center (US)
- GlaxoSmithKline (United States) (US)
- Probity Medical Research (CA)
- Guenther Dermatology Research Centre (CA)
- French Norwegian Foundation (FR)
- The University of Texas at San Antonio (US)
Publication Details
- Journal
- Allergy
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1111/all.70172
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00