The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids
Together, the results validated the use of colonoids as a pharmacological testing platform for phytochemicals, and that CA and SFN promote NRF2 activation and decrease inflammation in a human physiologically relevant UC model.
Authors
- Siri Sæterstad
- Torunn Bruland (ORCID: https://orcid.org/0000-0002-1568-2476)
- Ingunn Bakke (ORCID: https://orcid.org/0000-0003-0356-6184)
- Linn‐Karina Selvik
- Jeremy J. Johnson (ORCID: https://orcid.org/0000-0001-5489-2372)
- Abuzer Ali (ORCID: https://orcid.org/0000-0002-4313-3896)
- Rocío Rivera Rodríguez (ORCID: https://orcid.org/0000-0001-5570-1777)
Institutions
- Illinois College (US)
- Norwegian University of Science and Technology (NO)
- University of Illinois Chicago (US)
- University of Chicago (US)
- St Olav's University Hospital (NO)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3389/fphar.2025.1696576
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helse Midt-Norge
- Norges Forskningsråd
- National Institutes of Health
- Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet
- Faculty of Medicine and Health, University of Sydney