Characterization of Chitosan Nanocapsules as a Biocompatible Polymeric System

In this study, the solvent displacement method was used.This is a low-energy technique that generates a spontaneous "oil-in-water" nanoemulsion by diffusing ethanol from the oily phase to the aqueous phase.Subsequently, chitosan, a biocompatible and biodegradable cationic polymer, was incorporated, applying ionic gelation with sodium sulfate (Na 2 SO 4 ) to achieve uniform coatings.Atomic force microscopy (AFM) characterization revealed nanocapsules with defined morphology and regular topography.Analysis with WSxM 4.0 Beta 10 software revealed a partially ordered hexagonal arrangement, which was evidence of controlled synthesis and the potential of chitosan as a polymeric system.