Exosomal miR‐3126‐5p derived from cancer‐associated fibroblasts facilitates glycolysis to accelerate NSCLC progression by targeting KLF13 to activate the SH2B1/IRS1 axis
CAFs-derived exosomal miR-3126-5p enhanced glycolysis of NSCLC cells via targeting KLF13. KLF13 led to transcriptional inhibition of SH2B1 in NSCLC cells. SH2B1 interplayed with IRS1 to facilitate glycolysis of NSCLC cells. IRS1 promoted glycolysis of NSCLC cells via the activation of PI3K/AKT pathway.
Authors
- Hailong Ma (ORCID: https://orcid.org/0000-0003-4110-1417)
- Chenghui Wang (ORCID: https://orcid.org/0000-0001-8625-1748)
- Yingying Zheng (ORCID: https://orcid.org/0000-0002-5578-1524)
- Lina Wang (ORCID: https://orcid.org/0000-0003-1457-0015)
- Zhenyu Zhang (ORCID: https://orcid.org/0000-0002-2854-2798)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0002-2873-8854)
- Hengxiao Lu
- Shaoqiang Wang (ORCID: https://orcid.org/0000-0003-1149-8388)
Institutions
- Weifang Medical University (CN)
- Weifang People's Hospital (CN)
- Affiliated Hospital of Jining Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ctm2.70554
- Citations
- 1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.81