The Story of Localized Amyloidosis: Something Old and Something New – A Case Series

Localized amyloidosis is a rare benign disease characterized by extracellular deposition of misfolded proteins in a specific organ without systemic involvement, which might lead to organ dysfunction. Patients with localized amyloidosis do not develop systemic diseases such as cardiac, renal, hepatic, or nerve involvement. Typically, the localized disease is managed by surgical resection, while the systemic disease is treated with a combination chemotherapy and immunotherapy. However, some patients can have challenging clinical presentations, delaying diagnosis and organ dysfunction, and they might require systemic therapeutic intervention. There is a significant paucity of knowledge and data regarding clinical manifestations and the course of localized amyloidosis in various organs, and management can also be challenging. It is crucial to appropriately balance effective therapy with patient safety as treatment can lead to toxicity. Here, we discuss a series of patients who were presented with localized amyloidosis and one of whom needed systemic therapy.