Modeling kidney fibrosis and tubular regeneration in iPSC-derived kidney organoids
We present a reproducible human kidney organoid model that captures both fibrotic remodeling and tubular regeneration following clinically relevant injury. This platform offers a valuable tool for studying kidney-specific fibrosis dynamics and testing anti-fibrotic or pro-regenerative strategies.
Authors
- Shengbing Li (ORCID: https://orcid.org/0009-0001-2429-714X)
- Carla C. Baan (ORCID: https://orcid.org/0000-0003-2274-2788)
- Rafael Kramann (ORCID: https://orcid.org/0000-0003-4048-6351)
- Thierry P. P. van den Bosch
- Quincy Nlandu (ORCID: https://orcid.org/0000-0002-0486-4303)
- Martin J. Hoogduijn (ORCID: https://orcid.org/0000-0002-0217-8254)
Institutions
- Erasmus MC (NL)
- Erasmus MC Cancer Institute (NL)
- RWTH Aachen University (DE)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1186/s13287-025-04866-6
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00