Proficiency of Topical Platelet-Rich Plasma Over Vacuum-Assisted Closure for Chronic Wound Healing: A Clinical Prospective Comparative Study

Chronic wounds are a significant global health issue. Platelet-Rich Plasma (PRP) is a cost-effective and readily available blood derivative that stimulates cell proliferation and differentiation. Vacuum-Assisted Closure (VAC) is a novel method for treating wounds by inducing negative pressure wound healing. The present study aimed to investigate the advantages of PRP dressing over VAC application in aiding and enhancing chronic wound healing. This prospective randomised study included 102 patients aged 18–70 years. The patients were divided into the PRP (n = 50) and VAC (n = 52) groups. The patients in the PRP group received a single dose of autologous PRP injections, and the patients in the VAC group received an application. Treatment was assessed based on pain, tracking wound size reduction, and the time taken to completely heal the wound. All patients were followed for 12 weeks after PRP injection and VAC administration. The pain score was higher in the VAC group than that in the PRP group. The time taken for the complete healing of chronic wounds was 3–8 weeks in the PRP group, which was shorter than that in the VAC group (3–12 weeks). PRP dressings were more effective than VAC dressings in chronic wound healing.