Anatomical implant region – a critical determinant for the osteogenic potency of small extracellular vesicles and rhBMP-2
hUC-MSC-sEVs did not enhance screw implant osseointegration and slightly reduced new bone formation. In contrast, a low dose of rhBMP-2 (1.5 µg) promoted implant integration, with no additive effect when combined with sEVs. Notably, the osteogenic effect of rhBMP-2 was observed only at the proximal femoral site, indicating that anatomical location critically influences implant osseointegration. These findings highlight the importance of considering anatomical region when evaluating osteoinductive treatments and implant materials in small animal models.
Authors
- Andreas Traweger (ORCID: https://orcid.org/0000-0002-0220-4766)
- Thomas Freude (ORCID: https://orcid.org/0000-0003-4626-8179)
- Martin Holzleitner (ORCID: https://orcid.org/0009-0003-1882-0058)
- Sascha Senck (ORCID: https://orcid.org/0000-0001-8400-5121)
- Christian Deininger (ORCID: https://orcid.org/0000-0003-3235-0964)
- Eva Rohde (ORCID: https://orcid.org/0000-0001-8692-886X)
- Johann Fierlbeck
- Herbert Tempfer (ORCID: https://orcid.org/0000-0003-4043-4033)
- Mario Gimona (ORCID: https://orcid.org/0000-0002-2242-2015)
- Florian Wichlas
- Andrea Wagner (ORCID: https://orcid.org/0000-0002-0363-8099)
- Amelie Deluca (ORCID: https://orcid.org/0000-0002-8352-7371)
Institutions
- Medical University of Graz (AT)
- Paracelsus Medical University (AT)
- University of Applied Sciences Upper Austria (AT)
- Austrian Cluster for Tissue Regeneration (AT)
Publication Details
- Journal
- European Journal of Trauma and Emergency Surgery
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1007/s00068-025-03036-w
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Paracelsus Medizinische Privatuniversität
- European Regional Development Fund