Endothelial Transcription Factor EB Protects Against Doxorubicin-Induced Endothelial Toxicity and Cardiac Dysfunction
Taken together, endothelial TFEB protects against EC damage and cardiac dysfunction, constituting a potential target for treating cardiotoxicity induced by DOX. Our study provides new mechanistic insights into cardiotoxicity associated with chemotherapy.
Authors
- Richard C. Becker (ORCID: https://orcid.org/0000-0002-9878-7707)
- Guo‐Chang Fan (ORCID: https://orcid.org/0000-0002-0439-8277)
- Jun‐Lin Guan (ORCID: https://orcid.org/0000-0001-8720-8338)
- Sakthivel Sadayappan (ORCID: https://orcid.org/0000-0003-2006-7678)
- Darshini Desai
- Wa Du (ORCID: https://orcid.org/0000-0002-1518-7301)
- Yigang Wang (ORCID: https://orcid.org/0000-0002-0872-1860)
- Yanbo Fan (ORCID: https://orcid.org/0000-0002-3845-7562)
- Madison Ringer (ORCID: https://orcid.org/0009-0007-7029-8630)
- Chenran Wang
- Golam Iftakhar Khandakar
- Luis Tron Esqueda (ORCID: https://orcid.org/0000-0002-7034-287X)
Institutions
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1161/circulationaha.124.071774
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39