Macrophage-Specific E3 Ubiquitin Ligase TRIM31 Reduces Atherosclerotic Plaque Formation by Targeting LOX-1
TRIM31, an inducible, macrophage-enriched protective factor in atherosclerosis, restricts foam cell formation and inflammation by targeting LOX-1 for proteasomal degradation. These findings position TRIM31 as a promising therapeutic target for macrophage-driven atherogenesis.
Authors
- Lei Cao (ORCID: https://orcid.org/0000-0002-0755-6488)
- Ruiqing Ren (ORCID: https://orcid.org/0009-0003-6118-9601)
- Wenjing Xiong (ORCID: https://orcid.org/0000-0003-4701-5835)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-2782-1592)
- Wenqian Qi (ORCID: https://orcid.org/0009-0003-7022-6443)
- Liwen Yu (ORCID: https://orcid.org/0000-0003-3012-6993)
- Peili Bu (ORCID: https://orcid.org/0000-0001-5681-3711)
- Chengjiang Gao (ORCID: https://orcid.org/0000-0002-9365-4497)
- Wenhai Sui (ORCID: https://orcid.org/0000-0001-6114-0443)
- Meng Zhang (ORCID: https://orcid.org/0000-0002-3307-1820)
- Zijing Li (ORCID: https://orcid.org/0009-0006-7354-9282)
- Yun Zhang (ORCID: https://orcid.org/0000-0003-4432-6144)
- Na Li (ORCID: https://orcid.org/0000-0002-4112-0944)
- Shasha Wang (ORCID: https://orcid.org/0000-0002-1181-1672)
- Cheng Zhang (ORCID: https://orcid.org/0000-0003-3672-6543)
- Bingjie Liu (ORCID: https://orcid.org/0009-0008-5121-1437)
- Xiaohong Wang (ORCID: https://orcid.org/0000-0001-8925-5736)
- Xiao Wu (ORCID: https://orcid.org/0000-0002-6165-1697)
- Wei� Yang
- Lijuan Lyu (ORCID: https://orcid.org/0000-0003-4592-6766)
- Chunyu Kao
Institutions
- Shandong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Ministry of Education (TH)
- Ministry of Education (BD)
Publication Details
- Journal
- Circulation
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1161/circulationaha.125.076514
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00